In a brief letter published in Movement Disorders Clinical Practice , Catherine Martinez, BA, and Anne-Marie Wills, MD, MPH, of the Mass General Brigham Neuroscience Institute describe two patients with Parkinsons disease in which initiation of newer GLP1RAs was followed by marked changes in levodopa efficacy
The water-soluble nature of B12 means several things for patients : the vitamin requires regular dietary intake to maintain optimal levels, it can be lost during food preparation (particularly with prolonged cooking or boiling), and therapeutic doses are generally considered safe as excess is eliminated through the kidneys, though the body's substantial hepatic storage also plays a role in B12 metabolism
Never double-dose to compensate for a missed injection
If you search on Google Scholar using terms like "GLP-1 supplements," "GIP supplements," and "incretin mimetics," you will find many scientific papers about these topics