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However, while ephedrine stimulates multiple alpha and beta receptors affecting the cardiovascular system, synephrine only targets beta receptors responsible for fat mobilization, making it a safer alternative by avoiding side effects like tachycardia and hypertension

Then we need to make sure that we have enough in the toolbox for both the preventative and intervention side, highlight where the weakness is, target that group and help them address it. - Dr

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However, the relative instability of acid-cleavable linkers severely limits their application in ADCs because the released payload in the circulatory system may enter non-target cells, increasing the toxic effects of the drug