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Patients carrying certain FTO (rs9939609) or MC4R (rs17782313) variants may experience different appetite-suppression intensity and gastrointestinal adaptation timelines

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Sham-operated mice received identical surgical procedures, except the renal pedicle clamping

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Transcriptional regulators of the enzymes include the peroxisome proliferator-activated receptors (PPARs) and a transcription factor coactivator PGC-1a (and involve the retinoid X receptor), but the details of the process are tissue dependent

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