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The tonic NMDA receptor-mediated currents were significantly decreased in morphine-treated mice compared to saline-treated controls (Supplementary Fig

Such screening would follow or combine automated fractionation (LC-MS guided), reliable miniaturized persister assays, and orthogonal readouts (viability, metabolic reporters, single cell imaging) to limit false positives that inhibit or kill only growing cells (Petersen et al., 2024)