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As polar residues at these receptor locations are conserved across class B1 GPCRs and play a role in receptor activation for all receptors where studied 40,41,42,43,44,45 , stable vs transient interactions formed by peptide residues may also be associated with peptide efficacy at other class B1 receptors

Finally, market access issues, such as drug pricing and reimbursement by insurers, will be crucial for the success of new T2D therapies