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The resulting elevation in HSPA8 upregulates CD44 expression, collectively suppressing ferroptosis in HBV-associated hepatic cancer cells and thereby promoting tumor progression ( Figure 2 Several studies have affirmed the reciprocal relationship between viral hepatitis infection and ferroptosis

This suggests the significance of the hydrophobic nature of the interface in the FOXO4 FHD and p53 TAD interaction

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Szabo A, Kovacs A, Riba J, Djurovic S, Rajnavolgyi E, Frecska E