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Cardiac arrhythmias secondary to hypokalaemia during initial therapy have been reported

Populations at a higher risk of vitamin B12 deficiency include people who are vegetarian or vegan, exclusively breastfed infants of vegan women, older adults, those with gastrointestinal disorders or who have had gastrointestinal surgery, and people with an autoimmune condition known as pernicious anemia

By selectively inhibiting NNMT an enzyme central to energy regulation and fat metabolism this compound has demonstrated, in preclinical studies, the capacity to elevate intracellular NAD and SAM levels, suppress lipid accumulation in adipocytes, and reduce white adipose tissue mass in diet-induced obese mouse models

For primary weight management goals, the clinical evidence points clearly to semaglutide as the standard of care, with tirzepatide representing the most evidence-backed option for those who want greater weight loss