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Icotrokinra (JNJ-77242113), which is currently in development to treat patients with various IMIDs, is the first targeted oral peptide designed to selectively inhibit interleukin (IL)-23 signaling by blocking the IL-23 receptor on human immune cells

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Both are prescription-level compounds that require provider-guided dosing and blood-sugar monitoring, given the opposing glucose effects

But in other places, like the High Plains aquifer in the central United States, groundwater reserves were formed long ago and effectively arent recharged