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Bourla said that even when the drugmaker was negotiating its purchase of weight-loss drugmaker Metsera, initially announced in September 2025, Pfizer did not expect the cash-pay market for obesity drugs currently dominated by Eli Lilly and Co and Novo Nordisk to get so big, so fast

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For instance, a study presented at the American College of Gastroenterologys Annual Scientific Meeting noted that patients with a history of type 2 diabetes, tobacco use, and advanced chronic kidney disease were at a higher risk for developing acute pancreatitis after starting GLP-1 therapy