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In the semaglutide group, lower baseline body weight and waist circumference were each associated with reduced cardiovascular risk, corresponding to a 4% lower MACE risk per 5 kg decrease in body weight (hazard ratio [HR], 0.96

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A closer examination of circulating metabolites contributes to our understanding of the pathophysiology and may potentially provide markers of PsA disease: integrating this knowledge with current precision medicine efforts, clinicians could be guided in developing personalized interventions (for example, with aminoacidic monitoring and/or supplementation), based on the patients metabolic profile