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Claire Morrow, an orthopedic clinical specialist, told NewsNation that rapid weight loss causes the skin on the feet to appear loose or deflated because the skin cannot adjust quickly enough to the reduction in underlying fat volume

So the conclusion meant that the 2 monthly regime was solidified, the doctors who were previously prescribing to patient need, probably had their wrists slapped for not putting cost first

PMID: 24728259

Patients were randomized (n=456) to receive pemetrexed 500 mg/m2 intravenously over 10 minutes followed 30 minutes later by cisplatin 75 mg/m2 intravenously over two hours on Day 1 of each 21-day cycle or to receive cisplatin 75 mg/m2 intravenously over 2 hours on Day 1 of each 21-day cycle