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In the pre-experiments, we also used liquid chromatographymass spectrometry (LC-MS) to detect this peptide in mice blood at (83.5810.16) ng/ml in 1 hour after the mice were gavaged PGPIPN at 250g/kg body weight (data not shown)

doi: 10.3389/fnins.2025.1671955 Received 24 July 2025 Revised 10 December 2025 Accepted 16 December 2025 Published 13 January 2026 Volume 19 - 2025 Edited by Fangchen Gong, Shanghai Jiao Tong University, China Reviewed by Al-Shaimaa Faissal Ahmed, Minia University, Egypt John Sieh Dumbuya, Affiliated Hospital of Guangdong Medical University, China Updates Copyright 2026 Li, Wang, Ma, Peng, Wang, Wang, Li and Wang

\Circadian Rhythm Support: May help normalize disrupted sleep-wake cycles

D.RocchettiG.LuciniL.LorussoL.ManaraE.BertelliM.et al