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Gene Regulation: Downregulates senescence markers like p16 (INK4a) and p21 (Waf1), delaying cellular aging

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However, these emerging markers are still in the basic research stage, lacking large samples to validate their clinical sensitivity, specificity and predictive value, and the refinement of telomere length shortening measurement to the extent that it is substantially associated with the developmental potential of the embryo has yet to be thoroughly investigated