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In August 2025, the first generic liraglutide for weight loss received full FDA approval and coverage for brand-name liraglutide dropped by nearly 90% following that approval

The estimated hazard ratio for time to first MACE was 0.86 (95% CI: 0.77, 0.96) over the median follow-up duration of 49.6 months and 49.4 months for patients randomized to RYBELSUS and placebo, respectively

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Regulating Reward Systems: These drugs affect dopamine signaling, which may help with cravings, compulsions, and anhedonia (loss of pleasure)