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The fat and villi were removed, and the samples were incubated at 4 C for 15 min to isolate the crypts

As patients lose weight, blood pressure often naturally decreases, creating a paradoxical benefit: while semaglutide itself may cause mild blood pressure elevation in some individuals during early weeks, the subsequent weight loss typically produces a net reduction in systolic and diastolic readings

And the researchers who published it aren't writing editorials saying "maybe worry about this someday" - they're calling for DXA baselines, resistance training, and protein optimization to become standard of care from day one of GLP-1 therapy

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