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However, antidepressants come with several drawbacks, such as low remission rates (over 30% of patients do not achieve remission despite multiple treatments) [9] and poor tolerability, with many patients discontinuing their medication within the first few months [10]

As a complementary agent to incretin-based therapies (GLP-1 agonists and GLP-1/GIP dual agonists), cagrilintide has attracted substantial research attention for its additive weight-loss effects when co-administered with semaglutide-class molecules (the investigational combination known as cagrisema)

doi: 10.1073/pnas.1605635113 336 OnuoraS

Many nootropic ingredients have mixed evidence of their benefits, with even fewer research studies outright validating their potential