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Neuronally produced GLP1 is transported to the axon terminals of the producing cells and is there stored in synaptic vesicles until its eventual release into the synaptic cleft, or in case of extrasynaptic release, into the brain parenchyma (Zheng et al., 2014)

Using a technique called target trial emulation, which is designed to mimic the structure of a randomised trial using real-world data, they compared patients starting a GLP-1 medication with patients starting two other classes of diabetes drug: SGLT2 inhibitors and DPP4 inhibitors

I nuovi dati a 3 anni dellestensione SURMOUNT-1: mantenimento del peso e riduzione del 94% della progressione a diabete in soggetti con prediabete