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In contrast to the promoters with high CG amounts (CpG-rich promoters), the methylation of promoters containing low amounts of CGs (CpG-poor promoters) seems not to preclude the binding of RNA polymerase II (Pol II)

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It discusses the success of bremelanotide (derived from Melanotan II research) in later clinical trials for female sexual interest/arousal disorder, highlighting how the core mechanism identified with Melanotan II was refined into a more selective and tolerable drug for a specific indication