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Differences in trial duration, drug exposure, target engagement and outcome sensitivityall may have factored in

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It has been proposed that leptin exerts a negative regulatory effect on the release and action of ghrelin and that an increase in ghrelin level induced by fasting or weight loss arises because of the diminished inhibitory effect from leptin and probably also from PYY

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Older adults are generally more susceptible to infections due to a natural decline in immune function and possible co-existing health conditions

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