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CHICAGO (WLS) -- Geraldine Glass said her diabetes medication has been on back order for weeks because so many people are using the drug to lose weight

GLP-1 (glucagon-like peptide1) is a hormone made in the gut (and to some extent in the brain) that helps with: stimulating insulin secretion when glucose is high

Of great interest, infusion of IGF-I was shown to elicit a significant (~40%) increase in cerebromicrovascular density in the adult mouse brain[343], via stimulation of HIF-1 and its downstream effector, VEGF

Adding GIP action on top of GLP-1 seems to amplify the appetite-suppressing effects in a way that's greater than either alone