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Pivotally, BC is a prototypical multifactorial disease influenced by a complex interplay of genetic, hormonal, reproductive, environmental, and lifestyle factors 8

Melatonins potential to strengthen the BBB appears to involve the upregulation of tight junction proteins, including claudin-5, zonula occludens-1, and occluding [191], which help shield the brain from harmful substances in the bloodstream [192]

Lancet 381 , 19051915 (2013)

B12 deficiency is significantly more common in India than in most Western populations, affecting an estimated 47-70% of vegetarians and a substantial proportion of the general population due to dietary patterns