estrogen and glp 1 When my perimenopausal patients tell me they ‘feel more even’ on a GLP-1, I believe them. I think I know why., isn’t just a reproductive hormone. It supports the brain’s natural calm-down Tissue specificity and β-cell selectivity

it can render them completely meaningless

In rats, GCLC has a Km for glutamate that is about 10-fold higher than that of the GCL holoenzyme, which is higher than the cellular glutamate concentration in most tissues GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) non-allosteric feedback competitive inhibition by glutathione (GSH) (Ki = 2.3 mM) which involves binding of GSH to the glutamate and another site on the enzyme [8, 9] and (b) availability of its precursor, cysteine [1]

Novak M

A collection of over forty studies presented at the American Society of Clinical Oncology last month all point to a potential medical miracle: that GLP-1 drugs like Ozempic and Wegovy appear to be protecting patients against cancer