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Phenolic acids Phenolic acids (such as gallic acid, caffeic acid, protocatechuic acid or ferulic acid) are an important class of polyphenols widely distributed in vegetables and fruits, and the phenolic hydroxyl and carboxyl groups in their structures can react with ROS to exert anti-free-radical effects 248 , 249

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Although various therapeutic modality including systemic and topical pharmacological and procedural treatments are commonly available for melasma management, however, many of these treatments showed limited clinical response and accompany numerous unwanted adverse drug reactions

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