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A meta-analysis of five RCTs (over 4,400 people) in Endocrinology, Diabetes & Metabolism found that GI side effects were significantly more common at orforglipron doses of 12 mg or higher

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Altogether, about 1 in 8 US adults say they're currently taking one of the medicines, according to data from health policy research group KFF

Clinical eligibility for brand-name GLP-1 medications generally requires an adult patient to have a body mass index (BMI) of 30 or greater, or a BMI of 27 or higher paired with a weight-related health condition such as high blood pressure