[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Egecioglu E., Engel J.A., Jerlhag E
Warning signs requiring prompt evaluation include: Rectal bleeding or blood in stool Unexplained weight loss (beyond expected medication effect) Persistent change in bowel habits lasting more than a few weeks New-onset abdominal pain that differs from typical GLP-1 side effects Iron-deficiency anemia These symptoms warrant investigation regardless of medication use, as they may indicate various gastrointestinal conditions requiring diagnosis
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