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But an animal study suggests that muscle loss could possibly be less dramatic than expected.) Muscle loss among those taking GLP-1s is something Gabrielle Lyon, DO, a family medicine physician and author of Forever Strong , has noticed as welland she says the effects could potentially be detrimental

Distinguishing Cold Sensitivity from Other Semaglutide Side Effects Cold intolerance during GLP-1 therapy is separate from nausea, fatigue, or gastrointestinal discomfort, though patients sometimes experience multiple side effects simultaneously

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Many medications can lead to urinary retention and something we call overflow incontinence, which is when the bladder is not able to contract and expel urine effectively, leaving urine in the bladder, says Brooke D