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For the analyses of this estimand, missing values (unobserved due to patient loss to follow-up or other reasons) were assumed to be missing at random and were handled by multiple imputation using observed data in the placebo group

"It's like saying we have all these people who need to get from New York to DC, and rather than chartering a bus,we're going to tell everyone that they need to drive their own car." Updated to include a response from a White House spokesperson

Kyono, K., Hashimoto, T., Nagai, Y