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The warning includes urging patients to contact their doctors if they experience severe or persistent gastrointestinal symptoms. Though the updated label doesnt specifically connect the warning to blockages or ileus, both conditions are associated with gastrointestinal symptoms

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The timing of symptom onset also provides diagnostic clueswhile semaglutide side effects typically emerge shortly after initiation or dose increases, colitis can develop at any point during therapy

Rather than targeting one receptor pathway with high specificity, retatrutide activates three distinct hormone receptors simultaneously: GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon