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Clinical box A seemingly healthy 45-year-old man with abnormal transaminases A 45-year-old businessman had a routine medical examination, at which he was found to have a slightly enlarged liver

IFN- locally increases levels of CXCL9 and CXCL10 in the skin and serum of vitiligo patients, which in turn attracts pathogenic T cells expressing the CXCR3A receptor.18 A predominant lymphocytic infiltrate of CD8+ T cells has been observed in perilesional skin, correlating with disease activity.3 In vitiligo patients, CD8+ T lymphocytes recognize specific melanocyte antigens (MelanA, tyrosinase, gp100, tyrosinase-related proteins 1 and 2, Mart-1)

Melatonin, when mixed with certain medications, could result in a dangerous cocktail

Beumer, J