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The ratio of CP/CI-AMPAR expression covaried with the expression of NMDARs, forming a continuum from synapses with mostly CP-AMPARs and weaker and slower NMDAR-mediated components to synapses with mostly CI-AMPARs but a strong and fast NMDAR component (Bischofberger and Jonas, 2002

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Glucagon dynamics during hypoglycaemia and food-re-challenge following treatment with vildagliptin in insulin-treated patients with type 2 diabetes

Key findings across the STEP trials: Average weight loss of ~15% of body weight roughly 15 kg (33 lbs) for a 100 kg (220 lb) person 87% of patients lost at least 5% of body weight, compared to 31% on placebo Nearly 70% of patients lost at least 10% of body weight About 1 in 3 patients lost 20% or more Weight loss was maintained throughout the treatment period with continued medication use Significant improvements in blood pressure, blood sugar, cholesterol, and inflammatory markers alongside weight loss These results are dramatically better than any prior weight loss medication