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In contrast, subcutaneous fat , especially in the hips and thighs, exhibits greater alpha2-adrenergic activity and firmer connective tissue, making it harder to shrink quickly

Aratani S, Tagawa M, Nagasaka S, Sakai Y, Shimizu A, Tsuruoka S

If the niacinamide provides any subjective benefit, most patients would notice energy improvements within 4-8 weeks, which coincides with reaching higher semaglutide doses and the niacinamide dose scaling up proportionally

Instead, it promotes overall fat loss, and for many patients, that includes a noticeable reduction in abdominal and visceral fatthe most metabolically dangerous type of belly fat