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Notably, this stage exhibits peak levels of CYP3A4, a major enzyme responsible for metabolizing 3050% of clinically administered drugs 22,23

162 These general features also characterize HypB, except that the subunit-bridging coordination chemistry is distinct, involving two invariant Cys, one of which is part of an Cys -His motif positioned between the G2 and G3 loops, 691 and another embedded in the G3/switch II motif itself (Figure 38B)

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DSIP appears to play roles in stress response, pain modulation, hormonal regulation, and withdrawal from addictive substances