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This heightened permeability facilitates the translocation of bacterial endotoxins, such as LPS, into the systemic circulation

To examine the importance of this process, we took advantage of the potent GR inhibitor 2-AAPA (46), commonly used at 25 M (47)

Also, there was no typical morphological evidence of apoptosis, including swelling of the cytoplasm and organelles, nor rupture of the cell membrane (Xu et al., 2019)

A 2024 study summarized the clinical prospects of ferroptosis inducers across solid tumors, noting that structurally optimized compounds showed improved metabolic stability, enhanced antitumor efficacy in vivo , and better tumor targeting in GC through nanodelivery systems, marking steady progress toward clinical application (113)