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Both glutathione peroxidase 1 (GPx1) and glutathione peroxidase 2 (GPx2) are important for controlling Th2-dependent allergen-induced airway inflammation (43) with knockout of GPx1 shifting the Th cell bias toward Th1 and suppressing development of Th17 cells (44)

The following sections organize the mechanistic rationale into a structured framework to support experimental planning and outcome measurement

A deeper understanding of their underlying mechanisms is crucial for optimizing treatment strategies