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Several explanations have been proposed to clarify these differences such as different protocols (antibodies, dilutions, antigen retrieval, and cutoff) and the variable frequency of NF1-associated vs sporadic and radiation-associated malignant peripheral nerve sheath tumors between these cohorts

Statements Author contributions ZG: Writing original draft, Software, Conceptualization, Investigation

On the contrary, inducer binding drives a concerted change in both the conformation of the homodimer and DNA promoter to which it is bound, eliciting a transcriptional activation response via recruitment of RNA polymerase to what is now a strong promoter