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Instead, collectively, our analyses suggest that in non-interventional settings where most individuals consume meat daily (75233 g/day for European adults 37 ), clearance by the kidney and not dietary intake of TMAO precursors is the major determinant of fasting circulating TMAO levels and therefore of the excess cardiovascular risk associated with elevated TMAO (vegetarians and strict vegans aside, who are infrequent in the MetaCardis cohort with only 65/1741 participants reporting no red meat consumption)

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