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This is thought to be related to GLP-1s effects on the brains dopamine reward pathway, says Nitya Kumar, MD, an endocrinologist and an assistant professor of medicine at the Duke University School of Medicine in Durham, North Carolina

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Endocrinology 148 (10), 47044710 (2007)

The survey focused on these specialties because they all interact with patients who may be eligible to use GLP-1RA medications offlabel. The results, reported here for the first time, show that physician prescribing for off-label use of GLP-1RA medications is increasingly common, and often beneficial to patients