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When administered directly into the cerebrospinal fluid of mice, it showed dose-dependent pain-relieving effects that were blocked by naloxone, confirming involvement of opioid pathways

The effect is most noticeable as more even skin tone rather than dramatic lightening, and it works best in patients with hyperpigmentation, melasma, or uneven pigmentation rather than as a generalized skin-lightening agent

Clinical studies using 240mg daily of oral hyaluronic acid have shown improvements in joint pain and mobility after 8-12 weeks of supplementation

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