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Aberrations in temporal rhythms can both directly and indirectly enhance cardiovascular and cerebrovascular disease (Bggild and Knutsson, 1999), by enhancing sympathetic drive (Morris et al., 2012) increasing obesity (Shi et al., 2013), inducing insulin resistance and metabolic disorders (Marcheva et al., 2013), promoting premature aging (Brown et al., 2011), and inflammatory pathologies (Savvidis and Koutsilieris, 2012
Interleukin 6 and cardiovascular outcomes in patients with chronic kidney disease and chronic coronary syndrome
A virulent virus is one that causes a disease, and an avirulent virus is one that doesnt cause a disease (some vaccines use avirulent viruses)
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