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Its the same thing that happens when you cook an eggthe proteins change shape permanently

This is not a 'rebound effect' but rather a return to baseline physiology once the drug's influence on GLP-1 receptors diminishes

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96 Specifically, this compound decreases the levels of GSH and superoxide dismutase (SOD), increases malondialdehyde (MDA) levels, promotes E-cadherin expression, and lowers N-cadherin expression, 96 indicating that gambogenic acid can induce ferroptosis to inhibit TGF-1-induced EMT by disrupting the oxidative stress balance of melanocytes