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While the G6PD-d monocytes displayed the phenotypic hallmarks of M2 polarization (CD11b, CD209 expression), these cells were functionally deficient in M2 atheroprotective TGF and had increased expression of proinflammatory M1 cytokines TNF and MCP-1

(00:06:51) Brandon Owen: That's, I, I think I had a similar evolution, um, indirect bonding for me in residency because I came out where I was (00:07:00) learning like half of my cases with di direct and then half of were indirect

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however, because obesity and physical inactivity are strongly correlated with the condition, it is reasonable to expect that increasing physical activity and encouraging weight loss would be helpful