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adequate fibre and fluid intake help maintain bowel regularity Abdominal pain and dyspepsia (common): usually mild to moderate in severity Decreased appetite (very common): contributes to weight loss but may occasionally be excessive, requiring monitoring The mechanism underlying gastrointestinal effects relates to GLP-1 receptor activation in the gut, which delays gastric emptying and modulates gastrointestinal motility
Glutathione depletion shifts this balance toward autoimmunity
It slows down how quickly the stomach empties, helping you feel full longer and reducing the urge to snack
This is particularly important if you experience muscle cramps, which are sometimes reported alongside fatigue on semaglutide
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