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Native IGF-1, while powerful in its anabolic effects, has major limitations in research uses due to its short half-life of about 10 minutes and its high affinity for insulin-like growth factor binding proteins (IGFBPs), also known as igf-binding proteins

Wet beriberi, which refers to infantile thiamine deficiency, is characterized by cardiomyopathy, heart failure, warm extremities, and pulmonary edema, with early symptoms including fatigue, nausea, and mental suppression (, , )

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Recently, c-Myc has also been shown to contribute to the basal expression and induction of human GCL under conditions of oxidative stress