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10.1016/j.theriogenology.2021.04.005 2 Al-SafiZ

Its proposed mechanism is potent, selective blockade of the TREK-1 (KCNK2) two-pore-domain potassium channel

However, payers will remain cautious by implementing strict utilization controls and cost-containment strategies before expanding coverage broadly

Common Side Effects The most common adverse events reported in clinical trials include: Nausea: Reported by approximately 40% of participants, typically mild to moderate, related to melanocortin receptor activation in brainstem areas Flushing: Facial redness occurring in about 20% of users Injection site reactions: Pain, erythema, or bruising common with subcutaneous administration Headache: Affecting approximately 11% of participants These events are generally transient, occurring soon after administration and resolving within hours without intervention