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Interestingly, AMPK activates developmental Hedgehog signaling to promote polyamine biosynthesis in medulloblastoma by inducing translation of ODC (D'Amico et al., 2015), indicating that metabolism is a hub that connects development and cancer

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Certain neurologic conditions will require twice daily injections of PC, often followed by IV glutathione, but the maximum amount of PC per IVP is 2 vials or 10cc given up to twice daily

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