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Some pills that are commonly split include: Statins, like atorvastatin (Lipitor) and rosuvastatin (Crestor) Antidepressants, like citalopram (Celexa), paroxetine (Paxil), and sertraline (Zoloft) ACE inhibitors, like fosinopril sodium (Monopril), lisinopril (Prinivil and Zestril), and moexipril hydrochloride (Univasc) Angiotensin receptor blockers, like irbesartan (Avapro) and losartan potassium (Cozaar) Pills Not Suited for Splitting There are definitely medications you shouldn't split

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