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In the cohort of postmenopausal women, as opposed to those with the 677-CC genotype, those who had the lowest quartile of riboflavin intake and homozygous for the MTHFR 677 T allele were found to reap 1.8 and 2.6 times higher risk for incident osteoporotic fractures fragility fractures [37], respectively

In theory, this can reduce metabolic fatigue (cells running low on usable energy)

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