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This triggers an inflammatory response that can exacerbate tubular injury and promote the progression of DKD ( Pyroptosis can be identified by a combination of specific markers, which include TLR4, GSDMD, activation and release of pro-inflammatory IL-1 and IL-18, as well as the activation of cysteinyl aspartate specific proteinases, such as caspase-1, caspase-3, caspase-4, caspase-5, and caspase-11 ( In conclusion, pyroptosis in tubular cells plays an important role in the progression of DKD, and the underlying detailed mechanism requires further investigation