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Description

425,426 In the heart tissue of conditional frataxin knockout mice, increased mRNA levels of MFRN2, SEC15L1, and TFR1 and decreased mRNA levels of FPN1 indicate an activated response to cytoplasmic iron deficiency and increased mitochondrial iron input

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The authors advocate tailored monitoring protocols, including gradual dose titration at initiation and periodic renal function assessment in elderly patients to optimise safety outcomes in clinical practice

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