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Unlike M1 macrophages, M2 macrophages metabolize arginine using the arginase pathway, which is stimulated by cytokines such as IL-4, IL-6, IL-10, IL-13, TGF-, and other factors such as GM-CSF, PGE-2, cAMP, and catecholamines (Mart i Lndez and Reith, 2021)